About
Scope & Aims
Editorial office
Editorial board
Reviewers
Ethical standards and procedures
Abstracting and indexing
Contact
Articles & Issues
Current issue
Articles in press
Archive
For Authors
General rules
Guide for authors
Templates
Publication charge
For Reviewers
Guide for reviewers
Our reviewers
ORIGINAL PAPER
Response of erectile dysfunction to extracorporeal shock wave therapy in type 2 diabetic men
1
Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt
2
Basic Science Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt
Submission date: 2020-08-01
Acceptance date: 2020-11-27
Publication date: 2022-12-19
Physiother Quart. 2022;30(4):77-80
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Erectile dysfunction is a major complication of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effect of active vs. sham low-intensity extracorporeal shock wave therapy (Li-ESWT) on erectile dysfunction in T2DM men.
Methods:
Overall, 40 married T2DM men aged 40–50 years with erectile dysfunction were assigned to the study and the control group. Besides a 12-week daily administration of a 5-mg tablet of phosphodiesterase-5 inhibitor (PDE5I) tadalafil in both groups, the control group (n = 20) received sham Li-ESWT, while the study group (n = 20) received 2 active Li-ESWT (on the penile shaft with 1800 pulses and intensity of 0.09 mJ/mm2) sessions weekly for 3 consecutive weeks; then, the procedure was repeated for another 3 consecutive weeks, with a 3-week rest between the 2 procedures. Erectile dysfunction was assessed by the 5-item version of the International Index of Erectile Function (IIEF-5). Baseline, 1-month follow-up, 3-month follow-up, and 6-month follow-up IIEF-5 scores were documented.
Results:
After 1- and 3-month follow-up, there was a significant difference between the active and sham groups in favour of the active Li-ESWT group (p-value of 0.0001 and 0.01, respectively), but there was no significant difference between the groups at 6-month follow-up.
Conclusions:
Li-ESWT can increase the long-term efficacy of PDE5I in T2DM men with erectile dysfunction.
Erectile dysfunction is a major complication of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effect of active vs. sham low-intensity extracorporeal shock wave therapy (Li-ESWT) on erectile dysfunction in T2DM men.
Methods:
Overall, 40 married T2DM men aged 40–50 years with erectile dysfunction were assigned to the study and the control group. Besides a 12-week daily administration of a 5-mg tablet of phosphodiesterase-5 inhibitor (PDE5I) tadalafil in both groups, the control group (n = 20) received sham Li-ESWT, while the study group (n = 20) received 2 active Li-ESWT (on the penile shaft with 1800 pulses and intensity of 0.09 mJ/mm2) sessions weekly for 3 consecutive weeks; then, the procedure was repeated for another 3 consecutive weeks, with a 3-week rest between the 2 procedures. Erectile dysfunction was assessed by the 5-item version of the International Index of Erectile Function (IIEF-5). Baseline, 1-month follow-up, 3-month follow-up, and 6-month follow-up IIEF-5 scores were documented.
Results:
After 1- and 3-month follow-up, there was a significant difference between the active and sham groups in favour of the active Li-ESWT group (p-value of 0.0001 and 0.01, respectively), but there was no significant difference between the groups at 6-month follow-up.
Conclusions:
Li-ESWT can increase the long-term efficacy of PDE5I in T2DM men with erectile dysfunction.
REFERENCES (28)
1.
Ma C-C, Duan C-C, Huang R-C, Tang H-Q. Association of circulating cystatin C levels with type 2 diabetes mellitus: a systematic review and meta-analysis. Arch Med Sci. 2020;16(3):648–656; doi: 10.5114/aoms.2019.83511.
2.
Amelia R, Sahbudin DKNS-B, Yamamoto Z. Stress level and self-concept among type 2 diabetes mellitus patients in Indonesia. Fam Med Prim Care Rev. 2020;22(2):111–115; doi: 10.5114/fmpcr.2020.95313.
3.
Ismail AMA, Ezz El-din HM, Abdel Aal MEM. Impact of transcutaneous electrical nerve stimulation (TENS) on hyposalivation in type 2 diabetics. Biosci Res. 2019;16(1):690–694.
4.
Defeudis G, Gianfrilli D, Di Emidio C, Pofi R, Tuccinardi D, Palermo A, et al. Erectile dysfunction and its management in patients with diabetes mellitus. Rev Endocr Metab Disord. 2015;16(3):213–231; doi: 10.1007/s11154-015-9321-4.
5.
Ismail AMA, Abdelghany AI. Effect of adding a 2-month consequent continuous and interval elliptical aerobic training to once-daily 5-mg tadalafil administration on erectile dysfunction in obese men. Sex Disabil. 2022;40:129–139; doi: 10.1007/s11195-021-09720-0.
6.
Jóźwik S, Sierakowska M, Gajda R, Szczepańska-Gieracha J. Erectile dysfunction and mood disorders in patients undergoing cardiac rehabilitation. Physiother Quart. 2020;28(3):44–49; doi: 10.5114/pq.2020.95774.
7.
Binmoammar TA, Hassounah S, Alsaad S, Rawaf S, Majeed A. The impact of poor glycaemic control on the prevalence of erectile dysfunction in men with type 2 diabetes mellitus: a systematic review. JRSM Open. 2016;7(3):2054270415622602; doi: 10.1177/2054270415622602.
8.
Gentile I, Fusco F, Buonomo AR, Scotto R, Zappulo E, Pinchera B, et al. Prevalence and risk factors of erectile dysfunction in patients with hepatitis B virus or hepatitis C virus or chronic liver disease: results from a prospective study. Sex Health. 2018;15(5):408–412; doi: 10.1071/SH17168.
9.
Ortaç M, Küçükergin C, Salabaş E, Seçkin Ş, Kadıoğlu A. Effect of low-energy shockwave therapy on angiogenic factors in the penile tissue of diabetic rats. Turk J Urol. 2017;43(2):130–134; doi: 10.5152/tud.2017.35002.
10.
Ach T, Hasni Y, Abdelkarim AB, Maaroufi A, Kacem M, Chaieb M, et al. Clinical evaluation of erectile dysfunction in diabetic patients by IIEF5 score. Endocr Abstr. 2018;56:P409; doi: 10.1530/endoabs.56.P409.
11.
Rew KT, Heidelbaugh JJ. Erectile dysfunction. Am Fam Physician. 2016;94(10):820–827.
12.
Goldberg D, Andriessen A, Gold M. Radial shockwave therapy for male erectile rejuvenation in a dermatology and/or medical aesthetic practice. J Cosmet Dermatol. 2019;18(6):1596–1600; doi: 10.1111/jocd.13022.
13.
Pokorny P, Turcan P, Pokorny P, Prochazka M, Prochazkova J. Evaluation of radial extracorporeal shock wave therapy in the treatment of erectile dysfunction. J Sex Med. 2015;12(Suppl. 3):233.
14.
McMahon C. Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil. J Sex Med. 2004;1(3):292–300; doi: 10.1111/j.1743-6109.04042.x.
15.
Sáenz de Tejada I, Anglin G, Knight JR, Emmick JT. Effects of tadalafil on erectile dysfunction in men with diabetes. Diabetes Care. 2002;25(12):2159–2164; doi: 10.2337/diacare.25.12.2159.
16.
Yamaçake K, Carneiro F, Lourenço R, Piovesan AC, Srougi M, Nahas WC, et al. Low-intensity extracorporeal shockwave therapy improves erectile dysfunction in kidney transplant recipients. Results of a prospective, randomized, double blinded, sham controlled study. J Urol. 2019;201(Suppl. 4):e385; doi: 10.1097/01.JU.0000555751.59219.9d.
17.
Clavijo RI, Kohn TP, Kohn JR, Ramasamy R. Effects of low-intensity extracorporeal shockwave therapy on erectile dysfunction: a systematic review and meta-analysis. J Sex Med. 2017;14(1):27–35; doi: 10.1016/j.jsxm.2016.11.001.
18.
Chakraborty J, Chakraborty S, Chakraborty RM. Erectile dysfunction in type 2 diabetics: does it need more attention? J Integr Nephrol Androl. 2018;5(2):45; doi: 10.4103/jina.jina_32_17.
19.
Vardi Y, Appel B, Jacob G, Massarwi O, Gruenwald I. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol. 2010;58(2):243–248; doi: 10.1016/j.eururo.2010.04.004.
20.
Spivak L, Shultz T, Appel B, Verze P, Yagudaev D, Vinarov A. Low-intensity extracorporeal shockwave therapy for erectile dysfunction in diabetic patients. Sex Med Rev. 2021;9(4):619–627; doi: 10.1016/j.sxmr.2019.06.007.
21.
Fode M, Russo GI, Verze P. Therapeutic areas of Li-ESWT in sexual medicine other than erectile dysfunction. Int J Impot Res. 2019;31(3):223–230; doi: 10.1038/s41443-019-0114-2.
22.
Qiu X, Lin G, Xin Z, Ferretti L, Zhang H, Lue TF, et al. Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model. J Sex Med. 2013;10(3):738–746; doi: 10.1111/jsm.12024.
23.
Law YXT, Lee KCJ. Shockwave therapy for erectile dysfunction: is it really effective? J Integr Nephrol Androl. 2017;4(3):71–72; doi: 10.4103/jina.jina_15_17.
24.
Gruenwald I, Appel B, Vardi Y. Low-intensity extracorporeal shock wave therapy – a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J Sex Med. 2012;9(1):259–264; doi: 10.1111/j.1743-6109.2011.02498.x.
25.
Hisasue S-I, China T, Horiuchi A, Kimura M, Saito K, Isotani S, et al. Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction. Int J Urol. 2016;23(1):80–84; doi: 10.1111/iju.12955.
26.
Reisman Y, Hind A, Varaneckas A, Motil I. Initial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study. Int J Impot Res. 2015;27(3):108–112; doi: 10.1038/ijir.2014.41.
27.
Kim KS, Jeong HC, Choi SW, Choi YS, Cho HJ, Ha US, et al. Electromagnetic low-intensity extracorporeal shock wave therapy in patients with erectile dysfunction: a sham-controlled, double-blind, randomized prospective study. World J Mens Health. 2020;38(2):236–242; doi: 10.5534/wjmh.190130.
28.
Verze P, Capece M, Creta M, La Rocca R, Persico F, Spirito L, et al. Efficacy and safety of low-intensity shockwave therapy plus tadalafil 5 mg once daily in men with type 2 diabetes mellitus and erectile dysfunction: a matched-pair comparison study. Asian J Androl. 2020;22(4):379–382; doi: 10.4103/aja.aja_121_19.
Share
RELATED ARTICLE
| eISSN: | 2544-4395 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
