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ORIGINAL PAPER
Metabolic bone changes after intradialytic resistive exercise in regular haemodialysis patients
1
Department of Physical Therapy, Kasr El-Aini, Cairo University Hospitals, Cairo, Egypt
2
Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt
3
Department of Internal Medicine and Nephrology, Faculty of Medicine, Cairo University, Giza, Egypt
4
Faculty of Applied Medical Science, King Khalid University, Abha, Saudi Arabia
Submission date: 2020-01-16
Acceptance date: 2020-03-26
Publication date: 2021-03-22
Physiother Quart. 2021;29(1):24-29
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Mineral bone disease is a crucial factor that contributes to mortality and morbidity in haemodialysis patients. Intradialytic resistance exercise training can be valuable in stimulating bone formation. The aim of this study was to evaluate the metabolic bone changes after intradialytic resistive exercise training in regular haemodialysis patients.
Methods:
The study involved 60 patients on regular haemodialysis, aged 20–60 years. The patients were divided into 2 groups: a high parathyroid hormone group (parathyroid hormone over 800 pg/ml) and a low parathyroid hormone group (parathyroid hormone below 200 pg/ml), both groups randomly assigned into study and control groups. They received intradialytic resistive exercise 3 times per week for 3 months. Calcium, phosphorus, and parathyroid hormone were evaluated before and after the exercise period.
Results:
The training protocol proved to be effective in improving bone metabolism parameters, as there were statistically significant differences in the high parathyroid hormone exercise group. Parathyroid hormone and phosphorus decreased and calcium increased (p = 0.001, p = 0.012, and p = 0.025, respectively). In the low parathyroid hormone exercise group, phosphorus decreased significantly (p = 0.030) and calcium increased, although not significantly (p = 0.111), while parathyroid hormone non-significantly increased in the exercise group (p = 0.770), with a significant increase in the control group (p = 0.007). These results supported the positive effects of intradialytic resistive exercise in improving bone metabolism.
Conclusions:
Intradialytic resistive exercise training improves bone metabolism in haemodialysis patients.
Mineral bone disease is a crucial factor that contributes to mortality and morbidity in haemodialysis patients. Intradialytic resistance exercise training can be valuable in stimulating bone formation. The aim of this study was to evaluate the metabolic bone changes after intradialytic resistive exercise training in regular haemodialysis patients.
Methods:
The study involved 60 patients on regular haemodialysis, aged 20–60 years. The patients were divided into 2 groups: a high parathyroid hormone group (parathyroid hormone over 800 pg/ml) and a low parathyroid hormone group (parathyroid hormone below 200 pg/ml), both groups randomly assigned into study and control groups. They received intradialytic resistive exercise 3 times per week for 3 months. Calcium, phosphorus, and parathyroid hormone were evaluated before and after the exercise period.
Results:
The training protocol proved to be effective in improving bone metabolism parameters, as there were statistically significant differences in the high parathyroid hormone exercise group. Parathyroid hormone and phosphorus decreased and calcium increased (p = 0.001, p = 0.012, and p = 0.025, respectively). In the low parathyroid hormone exercise group, phosphorus decreased significantly (p = 0.030) and calcium increased, although not significantly (p = 0.111), while parathyroid hormone non-significantly increased in the exercise group (p = 0.770), with a significant increase in the control group (p = 0.007). These results supported the positive effects of intradialytic resistive exercise in improving bone metabolism.
Conclusions:
Intradialytic resistive exercise training improves bone metabolism in haemodialysis patients.
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