ORIGINAL PAPER
Differences between cardiorespiratory fitness in adult men with asymptomatic or mild SARS-COV-2 infections
1
Department of Sport Science, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
2
Department of Pharmacology, Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
3
Department of Engineering Physics, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung, Indonesia
Submission date: 2023-11-08
Acceptance date: 2024-01-19
Publication date: 2025-03-20
Corresponding author
Nia Sri Ramania
Institut Teknologi Bandung, Department of Sport Science Faculty. Ganesha No.10, Lb. Siliwangi, Kecamatan Coblong, Kota Bandung, Jawa Barat 40132
Institut Teknologi Bandung, Department of Sport Science Faculty. Ganesha No.10, Lb. Siliwangi, Kecamatan Coblong, Kota Bandung, Jawa Barat 40132
Physiother Quart. 2025;33(1):67-72
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aimed to measure and compare CRF levels between COVID-19-infected adults with asymptomatic and mild symptoms.
Methods:
The participants in this study included 50 adult men, who were further divided into 2 equal categories: mild symptomatic (MS) and asymptomatic (AS) groups. These participants received a series of anthropometry and Rockport 1.5-mile run tests. During the Rockport 1.5-mile run test, their heart rate (HR) was continuously monitored using a Polar V800 GPS. Following this test, Borg’s CR10-scale rating of perceived exertion (RPE) was employed.
Results:
One-way ANOVA statistical test results showed a significant difference (p = 0.007, ES = 0.140) between the MS and AS groups, where the VO2max in the AS group, was greater than the MS group (35.7 ± 7.1 vs 29.6 ± 8.4 ml/kg/min).
Conclusions:
Asymptomatic patients had a higher VO2max level than mildly symptomatic patients. Therefore, moderate-intensity exercise was recommended to increase CRF, thereby enhancing immunity and reducing the risk of contracting COVID-19.
This study aimed to measure and compare CRF levels between COVID-19-infected adults with asymptomatic and mild symptoms.
Methods:
The participants in this study included 50 adult men, who were further divided into 2 equal categories: mild symptomatic (MS) and asymptomatic (AS) groups. These participants received a series of anthropometry and Rockport 1.5-mile run tests. During the Rockport 1.5-mile run test, their heart rate (HR) was continuously monitored using a Polar V800 GPS. Following this test, Borg’s CR10-scale rating of perceived exertion (RPE) was employed.
Results:
One-way ANOVA statistical test results showed a significant difference (p = 0.007, ES = 0.140) between the MS and AS groups, where the VO2max in the AS group, was greater than the MS group (35.7 ± 7.1 vs 29.6 ± 8.4 ml/kg/min).
Conclusions:
Asymptomatic patients had a higher VO2max level than mildly symptomatic patients. Therefore, moderate-intensity exercise was recommended to increase CRF, thereby enhancing immunity and reducing the risk of contracting COVID-19.
REFERENCES (35)
1.
Liang C, Zhang W, Li S, Qin G. Coronary heart disease and COVID-19: a meta-analysis. Med Clin. 2021;156(11):547–54; doi: 10.1016/j.medcli.2020.12.017.
2.
Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
3.
Poon YR, Lin YP, Griffiths P, Yong KK, Seah B, Liaw SY. A global overview of healthcare workers’ turnover intention amid COVID-19 pandemic: a systematic review with future directions. Hum Resour Health. 2022;20(1):70; doi: 10.1186/s12960-022-00764-7.
4.
Ioannidis JPA. The end of the COVID-19 pandemic. Eur J Clin Invest. 2022;52(6):e13782; doi: 10.1111/eci.13782.
5.
Chen Y-M, Zheng Y, Yu Y, Wang Y, Huang Q, Qian F, Sun L, Song Z-G, Chen Z, Feng J, An Y, Yang J, Su Z, Sun S, Dai F, Chen Q, Lu Q, Li P, Ling Y, Yang Z, Tang H, Shi L, Jin L, Holmes EC, Ding C, Zhu T-Y, Zhang Y-Z. Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. EMBO J. 2020;39(24):e105896; doi: 10.15252/embj.2020105896.
6.
Piotrowicz K, Gąsowski J, Michel JP, Veronese N. Post-COVID-19 acute sarcopenia: physiopathology and management. Aging Clin Exp Res. 2021;33(10):2887–98; doi: 10.1007/s40520-021-01942-8.
7.
Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis. 2021;53(10):737–54; doi: 10.1080/23744235.2021.1924397.
8.
Moghimi N, Di Napoli M, Biller J, Siegler JE, Shekhar R, McCullough LD, Harkins MS, Hong E, Alaouieh DA, Mansueto G, Divani AA. The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection. Curr Neurol Neurosci Rep. 2021;21(9):44.; doi: 10.1007/s11910-021-01130-1.
9.
Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K, Abdalla AE, Abosalif KOA, Ahmed Z, Younas S. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health. 2020;13(12):1833–9; doi: 10.1016/j.jiph.2020.07.014.
10.
Chen X, Hong X, Gao W, Luo S, Cai J, Liu G, Huang Y. Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study. J Transl Med. 2022;20(1):216; doi: 10.1186/s12967-022-03407-6.
11.
Clavario P, De Marzo V, Lotti R, Barbara C, Porcile A, Russo C, Beccaria F, Bonavia M, Bottaro LC, Caltabellotta M, Chioni F, Santangelo M, Hautala AJ, Griffo R, Parati G, Corrà U, Porto I. Cardiopulmonary exercise testing in COVID-19 patients at 3 months follow-up. Int J Cardiol. 2021;340:113–8; doi: 10.1016/j.ijcard.2021.07.033.
12.
Alawna M, Amro M, Mohamed AA. Aerobic exercises recommendations and specifications for patients with COVID-19: a systematic review. Eur Rev Med Pharmacol Sci. 2020;24(24):13049–55; doi: 10.26355/eurrev_202012_24211.
13.
Fanget M, Bayle M, Labeix P, Roche F, Hupin D. Effects of cardiac telerehabilitation during covid-19 on cardiorespiratory capacities in patients with coronary artery disease. Front Physiol. 2022;13:837482; doi: 10.3389/fphys.2022.837482.
14.
Besnier F, Bérubé B, Malo J, Gagnon C, Grégoire C-A, Juneau M, Simard F, L’Allier P, Nigam A, Iglésies-Grau J, Vincent T, Talamonti D, Dupuy EG, Mohammadi H, Gayda M, Bherer L. Cardiopulmonary rehabilitation in Long-COVID-19 patients with persistent breathlessness and fatigue: the COVID-rehab study. Int J Environ Res Public Health. 2022;19(7):4133; doi: 10.3390/ijerph19074133.
15.
Stavrou VT, Vavougios GD, Boutlas S, Tourlakopoulos KN, Papayianni E, Astara K, Stavrou IT, Daniil Z, Gourgoulianis KI. Physical fitness differences, amenable to hypoxia-driven and sarcopenia pathophysiology, between sleep apnea and COVID-19. Int J Environ Res Public Health. 2022;19(2):669; doi: 10.3390/ijerph19020669.
16.
Fikenzer S, Kogel A, Pietsch C, Lavall D, Stöbe S, Rudolph U, Laufs U, Hepp P, Hagendorff A. SARS-CoV2 infection: functional and morphological cardiopulmonary changes in elite handball players. Sci Rep. 2021;11(1):17798; doi: 10.1038/s41598-021-97120-x.
17.
Moulson N, Petek BJ, Drezner JA, Harmon KG, Kliethermes SA, Patel MR, Baggish AL; Outcomes Registry for Cardiac Conditions in Athletes Investigators. SARS-CoV-2 cardiac involvement in young competitive athletes. Circulation. 2021;144(4):256–66; doi: 10.1161/CIRCULATIONAHA.121.054824.
18.
Singh TK, Zidar DA, McCrae K, Highland KB, Englund K, Cameron SJ, Chung MK. A post-pandemic enigma: the cardiovascular impact of post-acute sequelae of SARS-CoV-2. Circ Res. 2023;132(10):1358–73; doi: 10.1161/CIRCRESAHA.122.322228.
19.
Gervasi SF, Pengue L, Damato L, Monti R, Pradella S, Pirronti T, Bartoloni A, Epifani F, Saggese A, Cuccaro F, Bianco M, Zeppilli P, Palmieri V. Is extensive cardiopulmonary screening useful in athletes with previous asymptomatic or mild SARS-CoV-2 infection?. Br J Sports Med. 2021;55(1):54–61; doi: 10.1136/bjsports-2020-102789.
20.
Foster C, Florhaug JA, Franklin J, Gottschall L, Hrovatin LA, Parker S, Doleshal P, Dodge C. A new approach to monitoring exercise training. J Strength Cond Res. 2001;15(1):109–15.
21.
Papini GB, Carder C, Lightfoot CJ, Kubis HP, Bonomi AG, Sartor F. Quarter-mile walk test sensitive to training-induced fitness changes. J Sports Med Phys Fitness. 2019;59(11):1820–7; doi: 10.23736/S0022-4707.19.09445-3.
22.
Weiglein L, Herrick J, Kirk S, Kirk EP. The 1-mile walk test is a valid predictor of VO2max and is a reliable alternative fitness test to the 1.5-mile run in U.S. Air Force males. Mil Med. 2011;176(6):669–73; doi: 10.7205/milmed-d-10-00444.
23.
Kline GM, Porcari JP, Hintermeister R, Freedson PS, Ward A, McCarron RF, Ross J, Rippe JM. Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Med Sci Sports Exerc. 1987;19(3):253–9.
24.
Le Bert N, Clapham HE, Tan AT, Chia WN, Tham CYL, Lim JM, Kunasegaran K, Tan LWL, Dutertre C-A, Shankar N, Lim JME, Sun LJ, Zahari M, Tun ZM, Kumar V, Lim BL, Lim SH, Chia A, Tan Y-J, Tambyah PA, Kalimuddin S, Lye D, Low JGH, Wang L-F, Wan WY, Hsu LJ, Bertoletti A, Tam CC. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. J Exp Med. 2021;218(5):e20202617; doi: 10.1084/jem.20202617.
25.
Long QX, Tang XJ, Shi QL, Li Q, Deng H-J, Yuan J, Hu J-L, Xu W, Zhang Y, Lv F-J, Su K, Zhang F, Gong J, Wu B, Liu X-M, Li J-J, Qiu J-F, Chen J, Huang A-L. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020;26(8):1200–4; doi: 10.1038/s41591-020-0965-6.
26.
Kaminsky LA, Arena R, Myers J. Reference standards for cardiorespiratory fitness measured with cardiopulmonary exercise testing: data from the fitness registry and the importance of exercise national database. Mayo Clin Proc. 2015;90(11):1515–23; doi: 10.1016/j.mayocp.2015.07.026.
27.
Ismail AMA. Physical training and ocular yogic exercise in home: good alternative options to control the high-tension form of primary open angle glaucoma during the repeated COVID-19 waves. Int Marit Health. 2021;72(3):243–4; doi: 10.5603/IMH.2021.0046.
28.
Sloan RA, Haaland BA, Leung C, Padmanabhan U, Koh HC, Zee A. Cross-validation of a non-exercise measure for cardiorespiratory fitness in Singaporean adults. Singapore Med J. 2013;54(10):576–80; doi: 10.11622/smedj.2013186.
29.
Lee DC, Artero EG, Sui X, Blair SN. Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol. 2010;24(4 Suppl):27–35; doi: 10.1177/1359786810382057.
30.
Sloth M, Sloth D, Overgaard K, Dalgas U. Effects of sprint interval training on VO2max and aerobic exercise performance: a systematic review and meta-analysis. Scand J Med Sci Sports. 2013;23(6):e341–52; doi: 10.1111/sms.12092.
31.
Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, Carty C, Chaput J-P, Chastin S, Chou R, Dempsey PC, DiPietro L, Ekelund U, Firth J, Friedenreich CM, Garcia L, Gichu M, Jago R, Katzmarzyk PT, Lambert E, Leitzmann M, Milton K, Ortega FB, Ranasinghe C, Stamatakis E, Tiedemann A, Troiano RP, van der Ploeg HP, Wari V, Willumsen JF. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451–62; doi: 10.1136/bjsports-2020-102955.
32.
Ismail AMA. Online exercise rehabilitation to stable COPD patients during the second COVID wave: are physiotherapists able to help?. Adv Rehabil. 2020;34(4):48–9; doi: 10.5114/areh.2020.101592.
33.
Rintala P, McCubbin JA, Downs SB, Fox SD. Cross validation of the 1-mile walking test for men with mental retardation. Med Sci Sports Exerc. 1997;29(1):133–7; doi: 10.1097/00005768-199701000-00019.
34.
Severa M, Diotti RA, Etna MP, Rizzo F, Fiore S, Ricci D, Iannetta M, Sinigaglia A, Lodi A, Mancini N, Criscuolo E, Clementi M, Andreoni M, Balducci S, Barzon L, Stefanelli P, Clementi N, Coccia EM. Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection. PLoS Pathog. 2021;17(9):e1009878; doi: 10.1371/journal.ppat.1009878.
35.
Ramania N, Iwo M, Apriantono T, Winata B. The effect of social interaction and environment on aerobic dance on salivary cortisol. Physiother Q. 2020;28(3):14–20; doi: 10.5114/pq.2020.95770.
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