ORIGINAL PAPER
Exercise intervention as a protective modulator of dyslipidemia in men cigarette smokers
,
 
 
 
More details
Hide details
1
Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt
 
2
Department of Respiratory Therapy, College of Medical Rehabilitation Sciences, Taibah University, Medina, Saudi Arabia
 
3
Department of Cardiopulmonary Disorders and Geriatrics, Faculty of Physical Therapy, October 6 University, Giza, Egypt
 
 
Submission date: 2020-05-08
 
 
Acceptance date: 2020-10-28
 
 
Publication date: 2022-09-26
 
 
Physiother Quart. 2022;30(3):99-104
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Tobacco smoking is a major avoidable cause of morbidity. Smoking is one of the important factors which can alter normal lipid profile and it is among the major risk factors in the genesis of coronary atherosclerosis. The aim of this study was to determine the impact of high-intensity interval training on blood lipids and serum cotinine in Egyptian male smokers.

Methods:
Overall, 30 sedentary male smokers with dyslipidaemia, with mean age of 30.16 ± 3.22 years, were enrolled in a high-intensity interval training program calculated as 85–95% of their individualized maximum heart rate. The training program was applied for 30 minutes, 3 times per week for 8 weeks. Serum cotinine, low-density lipoprotein, high-density lipoprotein, triglycerides, and total cholesterol levels were measured before and after the intervention.

Results:
After the training program, a significant improvement (decrease) was observed in cotinine, low-density lipoprotein, triglycerides, and total cholesterol (by 39.94%, 7.13%, 5.09%, and 4.72%, respectively). Also, there was a significant improvement (increase) in high-density lipoprotein (by 17.07%).

Conclusions:
It is recommended for smokers to participate in high-intensity interval training to improve their lipid profile and decrease cotinine. These factors can play a role in reducing the risk for atherosclerosis.

REFERENCES (47)
1.
Fouda S, Kelany M, Moustafa N, Abushouk AI, Hassane A, Sleem A, et al. Tobacco smoking in Egypt: a scoping literature review of its epidemiology and control measures. East Mediterr Health J. 2018;24(2):198–215; doi: 10.26719/2018.24.2.198.
 
2.
Hajjar RR, Atli T, Al-Mandhari Z, Oudrhiri M, Balducci L, Silbermann M. Prevalence of aging population in the Middle East and its implications on cancer incidence and care. Ann Oncol. 2013;24(Suppl. 7):vii11–vii24; doi: 10.1093/annonc/mdt268.
 
3.
Amann M. Pulmonary system limitations to endurance exercise performance in humans. Exp Physiol. 2012;97(3):311–318; doi: 10.1113/expphysiol.2011.058800.
 
4.
Aune D, Schlesinger S, Norat T, Riboli E. Tobacco smoking and the risk of sudden cardiac death: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2018;33(6):509–521; doi: 10.1007/s10654-017-0351-y.
 
5.
Wigand JS. Additives, cigarette design and tobacco product regulation. A report to: World Health Organization Tobacco Free Initiative Tobacco Product Regulation Group. Kobe; 2006.
 
6.
Fouad H, El Awa F, El Naga RA, Emam AH, Labib S, Pali­pudi KM, et al. Prevalence of tobacco use among adults in Egypt, 2009. Glob Health Promot. 2016;23(Suppl. 2):38–47; doi: 10.1177/1757975913499801.
 
7.
El Ansari W, El Ashker S, Moseley L. Associations between physical activity and health parameters in adolescent pupils in Egypt. Int J Environ Res Public Health. 2010;7(4):1649–1669; doi: 10.3390/ijerph7041649.
 
8.
Negri E. Gender differences in smoking-related diseases. J Health Inequal. 2019;5(1):43; doi: 10.5114/jhi.2019.87830.
 
9.
Meenakshisundaram R, Rajendiran C, Thirumalaikolundusubramanian P. Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India. Tob Induc Dis. 2010;8(1):11; doi: 10.1186/1617-9625-8-11.
 
10.
Baselt RC. Disposition of toxic drugs and chemicals in man, 10th ed. Seal Beach: Biomedical Publications; 2017.
 
11.
Jang T-W, Kim H-R, Choi SE, Yim H-W, Lee H-E, My­ong J-P, et al. Smoking rate trends in Korean occupational groups: analysis of KNHANES 1998–2009 data. J Occup Health. 2012;54(6):452–458; doi: 10.1539/joh.12-0148-oa.
 
12.
Bhalala O. Detection of cotinine in blood plasma by HPLC MS/MS. MIT Undergrad Res J. 2003;8:45–50.
 
13.
Fathy M, Hamed M, Youssif O, Fawzy N, Ashour W. Association between environmental tobacco smoke exposure and lung cancer susceptibility: modification by antioxidant enzyme genetic polymorphisms. Mol Diagn Ther. 2014;18(1):55–62; doi: 10.1007/s40291-013-0051-6.
 
14.
Agaku IT, King BA, Husten CG, Bunnell R, Ambrose BK, Hu SS, et al. Tobacco product use among adults – United States, 2012–2013. MMWR. Morb Mortal Wkly Rep. 2014;63(25):542–547.
 
15.
WHO and ARE-Ministry of Health & Population. Egypt national STEPwise survey of non-communicable diseases risk factors. 2012.
 
16.
Nayak M, Dodiya D, Nayak J. Assessment of lipid profile in smokers versus non-smokers. Int J Res Med. 2016;5(2):26–29.
 
17.
Jain RB, Ducatman A. Associations between smoking and lipid/lipoprotein concentrations among US adults aged 20 years. J Circ Biomark. 2018;7:1849454418779310; doi: 10.1177/1849454418779310.
 
18.
Huang LZ, Grady SR, Quik M. Nicotine reduces L-DOPA-induced dyskinesias by acting at 2* nicotinic receptors. J Pharmacol Exp Ther. 2011;338(3):932–941; doi: 10.1124/jpet.111.182949.
 
19.
Kopa PN, Pawliczak R. Health consequences of smoking – focusing on alternative smoking methods. Polish J Allergol. 2019;6(3):100–109; doi: 10.5114/pja.2019.88291.
 
20.
Hong X-Y, Lin L, Gu W-W. Risk factors and therapies in vascular diseases: an umbrella review of updated systematic reviews and meta-analyses. J Cell Physiol. 2019;234(6):8221–8232; doi: 10.1002/jcp.27633.
 
21.
Marcus BH, Lewis BA, Hogan J, King TK, Albrecht AE, Bock B, et al. The efficacy of moderate-intensity exercise as an aid for smoking cessation in women: a randomized controlled trial. Nicotine Tob Res. 2005;7(6):871–880; doi: 10.1080/14622200500266056.
 
22.
Bartlett JD, Close GL, MacLaren DPM, Gregson W, Drust B, Morton JP. High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence. J Sports Sci. 2011;29(6):547–553; doi: 10.1080/02640414.2010.545427.
 
23.
Koubaa A, Triki M, Trabelsi H, Baati H, Sahnoun Z, Hakim A. The effect of a 12-week moderate intensity interval training program on the antioxidant defense capability and lipid profile in men smoking cigarettes or hookah: a cohort study. ScientificWorldJournal. 2015;2015:639369; doi: 10.1155/2015/639369.
 
24.
Whitehurst M. High-intensity interval training: an alternative for older adults. Am J Lifestyle Med. 2012;6(5):382–386; doi: 10.1177/1559827612450262.
 
25.
Sedeaud A, Marc A, Marck A, Dor F, Schipman J, Dor­sey M, et al. BMI, a performance parameter for speed improvement. PLoS One. 2014;9(2):e90183; doi: 10.1371/journal.pone.0090183.
 
26.
Racil G, Coquart JB, Elmontassar W, Haddad M, Goebel R, Chaouachi A, et al. Greater effects of high- compared with moderate-intensity interval training on cardio-metabolic variables, blood leptin concentration and ratings of perceived exertion in obese adolescent females. Biol Sport. 2016;33(2):145–152; doi: 10.5604/20831862.1198633.
 
27.
Robergs RA, Landwehr R. The surprising history of the “HRmax = 220 – age” equation. J Exerc Physiol Online. 2002;5(2):1–10.
 
28.
Haasova M, Warren FC, Ussher M, Van Rensburg KJ, Faulkner G, Cropley M, et al. The acute effects of physical activity on cigarette cravings: exploration of potential moderators, mediators and physical activity attributes using individual participant data (IPD) meta-analyses. Psychopharmacology. 2014;231(7):1267–1275; doi: 10.1007/s00213-014-3450-4.
 
29.
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–952; doi: 10.1016/s0140-6736(04)17018-9.
 
30.
Brunner H, Cockcroft JR, Deanfield J, Donald A, Ferrannini E, Halcox J, et al. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23(2):233–246; doi: 10.1097/00004872-200502000-00001.
 
31.
Kozub M, Gachewicz B, Kasprzyk M, Roszak M, Gasio­rowski L, Dyszkiewicz W. Impact of smoking history on postoperative complications after lung cancer surgery – a study based on 286 cases. Kardiochir Torakochirurgia Pol. 2019;16(1):13–18; doi: 10.5114/kitp.2019.83940.
 
32.
Ahammed B, Maniruzzaman MD, Kundu S, Al Mahmud J, Ferdausi F. Prevalence and risk factors associated with tobacco smoking among adults in India: a nationally representative household survey. Fam Med Prim Care Rev. 2019;21(4):307–317; doi: 10.5114/fmpcr.2019.86505.
 
33.
Gabr HM, Allam HK, Abdallah AR. Smoking among administrative university employees: prevalence and degree of nicotine dependence. Egypt J Occup Med. 2019;43(2):259–268; doi: 10.21608/EJOM.2019.31423.
 
34.
Alvarez C, Ramirez-Campillo R, Martinez-Salazar C, Castillo A, Gallardo F, Gomes Ciolac E. High-intensity interval training as a tool for counteracting dyslipidemia in women. Int J Sports Med. 2018;39(5):397–406; doi: 10.1055/s-0044-100387.
 
35.
Pavey TG, Gartner CE, Coombes JS, Brown WJ. Assessing the effectiveness of high intensity interval training (HIIT) for smoking cessation in women: HIIT to quit study protocol. BMC Public Health. 2015;15(1):1309; doi: 10.1186/s12889-015-2631-3.
 
36.
Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115(24):3086–3094; doi: 10.1161/CIRCULATIONAHA.106.675041.
 
37.
Elmer DJ. Effect of 8 weeks of high-intensity interval training versus traditional endurance training on the blood lipid profile in humans. Doctoral dissertation. Auburn: Auburn University; 2013.
 
38.
Musa DI, Adeniran SA, Dikko AU, Sayers SP. The effect of a high-intensity interval training program on high-density lipoprotein cholesterol in young men. J Strength Cond Res. 2009;23(2):587–592; doi: 10.1519/JSC.0b013e318198fd28.
 
39.
Ndlovu P. The effect of high intensity interval training and detraining on the health-related outcomes of young women. Master’s thesis. Stellenbosch: Stellenbosch University; 2013.
 
40.
ElDeeb AM, Elsisi HF, Lasheen YR. Response of lipids, estradiol level, and liver size to diet and high-intensity interval training in postmenopausal women with fatty liver. Bull Fac Phys Ther. 2018;23(2):69–76; doi: 10.4103/bfpt.bfpt_6_18.
 
41.
Pedersen BK, Saltin B. Exercise as medicine – evidence form prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25(Suppl. 3):1–72; doi: 10.1111/sms.12581.
 
42.
Linke SE. Intermittent exercise in response to nicotine cravings in the context of an Internet-based smoking cessation program. Doctoral dissertation. San Diego: University of California; 2011.
 
43.
Prapavessis H, De Jesus S, Harper T, Cramp A, Fitzge­orge L, Mottola MF, et al. The effects of acute exercise on tobacco cravings and withdrawal symptoms in temporary abstinent pregnant smokers. Addict Behav. 2014;39(3):703–708; doi: 10.1016/j.addbeh.2013.10.034.
 
44.
Scerbo F, Faulkner G, Taylor A, Thomas S. Effects of exercise on cravings to smoke: the role of exercise intensity and cortisol. J Sports Sci. 2010;28(1):11–19; doi: 10.1080/02640410903390089.
 
45.
Pignataro RM, Ohtake PJ, Swisher A, Dino G. The role of physical therapists in smoking cessation: opportunities for improving treatment outcomes. Phys Ther. 2012;92(5):757–766; doi: 10.2522/ptj.20110304.
 
46.
Horn K, Branstetter S, Zhang J, Jarrett T, O’Hara Tompkins N, Anesetti-Rothermel A, et al. Understanding physical activity outcomes as a function of teen smoking cessation. J Adolesc Health. 2013;53(1):125–131; doi: 10.1016/j.jadohealth.2013.01.019.
 
47.
Roberts V, Maddison R, Simpson C, Bullen C, Prapavessis H. The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect, and smoking behaviour: systematic review update and meta-analysis. Psychopharmacology. 2012;222(1):1–15; doi: 10.1007/s00213-012-2731-z.
 
eISSN:2544-4395
Journals System - logo
Scroll to top